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Fasenra (Benralizumab Prefilled Syringes), swelling of the eyelids, face, lips, hands, or feet, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Fasenra should be kept inside its original package and protected from light. Below are some of the important considerations to discuss with your doctor before you start receiving Fasenra. Long-term side effects are side effects that either: Your doctor or pharmacist can answer any questions you may have about Fasenra and long-term side effects. Off-label drug use is when a drug thats approved for one condition is used for a different one thats not approved. Neither drug is a rescue inhaler. Tell them about all prescription, over-the-counter, and other drugs you take. If youre not sure if youll need to get prior authorization for Fasenra, contact your insurance company. Fasenra is approved to treat severe eosinophilic asthma in children ages 12 years and older. This reduces the number of eosinophils in your airways. With severe eosinophilic asthma, you have high levels of eosinophils in your body. It may also be called a monoclonal antibody. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. Steroids are medications that are made from a combination of chemicals. Each vial, autoinjector pen, or syringe contains one dose of Nucala. Fasenra contains the active drug benralizumab, and Dupixent contains the drug dupilumab. Keep each Fasenra pen in its original carton until its time to give yourself a dose. But animal studies dont always predict what may occur in humans. This is a type of drug that attaches to proteins in your immune system (your bodys defense against infection). With eosinophilic asthma, you also have high levels of eosinophils (a type of white blood cell). Benralizumab injection is used together with other medicines to treat severe asthma. Fasenra is a monoclonal antibody (IgG1, kappa) that binds to IL-5R, the alpha subunit of the human interleukin-5 receptor. This means benralizumab is the ingredient that makes Fasenra work. Fasenra is not indicated for the treatment of other eosinophilic conditions such as eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) or hypereosinophilic syndrome (HES). But if your fever lasts more than 3 days or is higher than 103F (about 39.4C), tell your doctor. Examples of drugs that may be used to treat severe eosinophilic asthma include: You may wonder how Fasenra compares to other medications that are prescribed for similar uses. You might also be interested in how Fasenra compares with Dupixent. (An active drug is an ingredient that makes a medication work.) With eosinophilic asthma, you also have high levels of eosinophils (a type of white blood cell). Keep in mind that side effects of a drug can depend on: Your doctor or pharmacist can tell you more about the potential side effects of Fasenra. Fasenra may not be right for you if you have certain medical conditions or other factors affecting your health. In comparison, 2% of people who took a placebo had a fever. The improvement in exacerbation rates started to appear 4 weeks after administration with Fasenra, suggesting that it begins to have a beneficial effect shortly after patients start taking it. There have been no formal interaction studies conducted with Fasenra, according to the product information, and no interactions are documented. If you no longer need to take Fasenra and have leftover medication, its important to dispose of it safely. Since oxygen is carried in air, this condition reduces how much oxygen reaches the cells inside your body. Fasenra may also be used off-label for other conditions. Eosinophils are one of multiple types of cells and mediators that are involved in inflammation, and inflammation is an important component in the pathogenesis of asthma and some other conditions. These cells cause inflammation (swelling) and trigger asthma flare-ups. Activation of eosinophils can lead to the release of substances that promote inflammation. If you and your doctor determine that Fasenra is safe and effective for you, youll likely take it long term. Fasenra can cause mild or serious side effects. Before you begin treatment, talk with your doctor and pharmacist about this. If you have serious side effects from Fasenra, call your doctor right away. Mild side effects of Fasenra that have been reported include: Mild side effects of many drugs may go away within a few days to a couple of weeks. Eosinophils (a type of white blood cell) are found in your airways. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. They may recommend treatments to help you feel better. In certain people, Nucala is also approved to treat: Each syringe or pen contains one dose of Fasenra. The IL-5 receptor regulates the growth, multiplication, and function of eosinophils and basophils. Fasenra is FDA-approved to treat severe eosinophilic asthma in adults and children ages 12 years and older. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Fasenra should not be shaken, frozen, or exposed to heat. Fasenra and Nucala are kinds of biologic medications, which means theyre made from living cells rather than chemicals. However, clinical trials of similar medications suggest that if Fasenra is used during the third trimester of pregnancy (week 28 through the birth of your baby), the drug will pass to the growing fetus. This will help prevent skin problems from the injections. Gastrointestinal problems. Wash your hands and clean the injection site with an alcohol swab. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps. The dose of this medicine will be different for different patients. But you wont take Fasenra every day, and it isnt effective during asthma flare-ups. Before leaving the office or clinic, make sure that you have an appointment for your next Fasenra injection scheduled. It also enhances the apoptosis of basophils. (Conditions or factors that could prevent your doctor from prescribing a medication are called contraindications.) redness of the skin, swelling of the eyelids, face, lips, hands, or feet, tightness in the chest, trouble swallowing, cough, dizziness, and. These lists contain examples of more common side effects that can occur with Fasenra, with Nucala, or with both drugs (when taken individually). Fasenra works by attaching to certain white blood cells called eosinophils. For more information on the effectiveness of Fasenra, see the Fasenra uses section below. These can be life-threatening and require immediate medical attention. In animal studies, Fasenra didnt cause harm to the offspring of animals given the drug. Its target is the interleukin-5 receptor (IL-5 receptor), to which it binds via the alpha subunit of the receptor. chronic obstructive pulmonary disease (COPD). It is also used in patients whose asthma has an eosinophilic phenotype. Fasenra comes in two forms: a prefilled syringe and a prefilled autoinjector pen. But if they become bothersome, talk with your doctor or pharmacist. The FDA is currently deciding whether to approve Fasenra for treating nasal polyps. This is a subtype of asthma that is characterized by high numbers of eosinophils in the blood. Both Fasenra and Nucala (mepolizumab) are prescribed to treat severe eosinophilic asthma in adults and some children. Heres a short list of some of the mild side effects that Fasenra can cause. So you shouldnt them to treat asthma flare-ups or a severe kind of asthma called status asthmaticus. Serious side effects from Fasenra arent common, but they can occur. Check the liquid in the Fasenra Pen. Fasenra (Benralizumab): Asthma Uses, Dosage, Side Effects - RxList